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Dosage Efficacy Indications Multimodal approach to post-operative pain Prescribing Information Safety and Tolerability Safety Information
Safety and TolerabilityRAYZON® (parecoxib sodium) – Well-tolerated with decreased risk of gastroduodenal mucosal injury vs ketorolac1

COX-2 inhibitors have analgesic efficacy comparable with that of conventional nonsteroidal anti-inflammatory drugs (NSAIDs) and may be associated with reduced gastrointestinal (GI) side effects compared with conventional NSAIDs1,2

RAYZON® (parecoxib sodium) has significantly (p<0.05) lower incidence of upper GI ulceration and/or erosion vs. ketorolac1Indications

* Significantly different from both other treatments, p<0.05

Two-center, double-blind, randomized, placebo-controlled study of healthy 65-75 year-old subjects (n=94) whose baseline endoscopy showed no gastric or duodenal lesions given either parecoxib sodium 40 mg b.i.d. for 7 days, ketorolac 15 mg q.i.d. for 5 days, or placebo for 7 days1

RAYZON® (parecoxib sodium) – Less likely to be associated with excessive bleeding during surgery3

RAYZON® (parecoxib sodium) (40 mg BID) demonstrated little to no effect on platelet aggregation while ketorolac (30 mg QID) significantly decreases aggregation3

Platelet response to arachidonate at baseline and on last drug administration day in elderly individuals. Statistical comparisons are based on changes from baseline:3
* indicated p<0.001 for change from vs ketorolac;
** indicated p<0.001 for changes from baseline vs placebo. None of the differences between parecoxib sodium and placebo were statistically significant

 

The study of elderly participants was a single centre, double-blind, randomised, active- and placebo-controlled, parallel-group comparison of parecoxib sodium 10 mg twice daily intravenously. parecoxib sodium 40 mg twice daily intravenously, ketorolac 15 mg four times daily intravenously (the recommended dosage for patients over the age of 65 years) or placebo3

Abbreviations:BID: twice daily; GI: gastrointestinal; IV: intravenously; QID: four times daily.ReferencesStoltz RR, Harris SI, Kruss ME, et al. Upper GI mucosal effects of parecoxib sodium in healthy elderly subjects. Am. J. Gastroenterol. 2002;97(1):65-71.Gajraj NM. Cyclooxygenase-2 inhibitors. Anesthesia & Analgesia. 2003;96(6):1720-38.Noveck RJ, Richard C. Parecoxib Sodium does not impair platelet function in healthy elderly and non-elderly individuals: two randomised, controlled trials. Clin Drug Invest. 2001;21(7):465-76.
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