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Sutent

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Interactions

In vitro studies indicate that SUTENT® (sunitinib) neither induces nor inhibits major CYP enzymes, including CYP3A4.1

When SUTENT® (sunitinib) is co-administered with other medicines, there is a potential for medicine interaction:1
  • The dose of SUTENT® (sunitinib) may need to be reduced based on tolerability when co-administered with CYP3A4 inhibitors.
  • The dose of SUTENT® (sunitinib) may need to be increased when it is co-administered with potent CYP3A4 inducers.

Concomitant administration with inhibitors should be avoided, or the selection of an alternate concomitant medication with no or minimal potential to inhibit CYP3A4, should be considered.1

If this is not possible, the dosage of SUTENT® (sunitinib) may need to be reduced to a minimum of 37,5 mg daily based on tolerability and/or clinical response.1

Concomitant administration with inducers should be avoided, or the selection of an alternate concomitant medication with no or minimal potential to induce CYP3A4, should be considered.1

If this is not possible, the dosage of SUTENT® (sunitinib) may need to be increased in 12,5 mg increments up to 87,5 mg per day based on tolerability and/or clinical response.1

Clinical response and tolerability should be carefully monitored.1
References:Pfizer Laboratories (Pty) Ltd. SUTENT® (sunitinib) 12,5 mg, 25 mg, 50 mg capsules. Final Approved Package Insert - 12 July 2021
PP-SUT-ZAF-0084

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