This site is intended only for all Healthcare Professionals residing in South Africa




Sign InLog Out Our medicinesTherapy areasExplore contentExplore contentEventsDownloadable materialsVideosLet’s connectLet's ConnectContact usPfizer medical information



Pancreatic neuroendocrine tumours (pNET)Pancreatic neuroendocrine tumours (pNET)ContraindicationsDosage and AdministrationEfficacyInteractionsMechanism of actionPost-marketing ExperiencePrescribing InformationSafetySpecial PopulationsSpecial Warnings and PrecautionsMetastatic renal cell carcinoma (mRCC)Metastatic renal cell carcinoma (mRCC)ContraindicationsDosage and AdministrationEfficacyInteractionsMechanism of actionPost-marketing ExperiencePrescribing InformationSafetySpecial PopulationsSpecial Warnings and PrecautionsGastrointestinal stromal tumour (GIST)Gastrointestinal stromal tumour (GIST)
ContraindicationsDosage and AdministrationEfficacyInteractionsMechanism of actionPost-marketing ExperiencePrescribing InformationSafetySpecial PopulationsSpecial Warnings and Precautions
Post-marketing ExperienceThe following adverse events have been identified during post-approval use of SUTENT® (sunitinib):Infection and infestations1
  • Cases of serious infection (with or without neutropenia) in some cases with fatal outcome. The infections most commonly observed with SUTENT® (sunitinib treatment were respiratory infections (e.g., pneumonia, bronchitis), urinary tract infections, skin infections (e.g., cellulitis) sepsis/septic shock and abscess (e.g., oral, genital, anorectal, skin, limb, visceral). Infections may be bacterial or fungal.
Blood and lymphatic system disorders1
  • Cases of thrombotic microangiopathy and haemolytic uraemic syndrome have been reported. Temporary suspension of SUTENT® (sunitinib) is recommended. Following resolution, treatment may be resumed at the discretion of the treating medical practitioner.
Immune system disorders1
  • Hypersensitivity reactions, including angioedema.
Endocrine disorders1
  • Cases of hyperthyroidism some followed by hypothyroidism, and thyroiditis.
Metabolism and nutrition disorders1
  • Cases of Tumour Lysis Syndrome, some fatal. Decreases in blood glucose, in some cases clinically symptomatic.
Nervous system disorders11
  • Taste disturbance, including ageusia.
Cardiac disorders1
  • Cardiac failure, congestive cardiac failure, prolonged QT interval and torsade de pointes. Cardiomyopathy, myocardial ischaemia, left ventricular failure and myocardial infarction, in some cases with fatal outcome.
Vascular disorders1
  • Cases of arterial thromboembolic events, sometimes fatal. The most frequent events included cerebrovascular accident, transient ischaemic attack, ischaemic stroke and cerebral infarction. Risk factors associated with arterial thromboembolic events, in addition to the underlying malignant disease and age 2 65 years, included hypertension, diabetes mellitus and prior thromboembolic disease.
Respiratory, thoracic and mediastinal disorders1
  • Pulmonary embolism, in some cases with fatal outcome.
Gastrointestinal disorders1
  • Pancreatitis, gastrointestinal perforation, oesophagitis.
Hepato-biliary disorders1
  • Hepatic failure (including fatal events), hepatitis B reactivation (including fatal events) and cholecystitis, particularly acalculous cholecystitis.
Skin and subcutaneous tissue disorders1
  • Cases of pyoderma gangrenosum, erythema multiforme and Stevens-Johnson syndrome.
Musculoskeletal and connective tissue disorders1
  • Cases of myopathy and/or rhabdomyolysis, with or without acute renal failure, in some cases with fatal outcome. Most of these patients had pre-existing risk factors and/or were receiving concomitant medications known to be associated with these adverse reactions. Patients with signs or symptoms of muscle toxicity should be managed as per standard medical practice.
  • Cases of fistula formation, sometimes associated with tumour necrosis and/or regression, in some cases with fatal outcome.
  • Cases of osteonecrosis of the jaw (ONJ), most of which occurred in patients who had identified risk factors for ONJ, in particular exposure to IV bisphosphonates and/or a history of dental disease requiring invasive dental procedures.
Renal and urinary disorders1
  • Cases of renal impairment and/or failure, in some cases with fatal outcome. Cases of proteinuria and cases of nephrotic syndrome.
  • Increased TSH and increased blood uric acid.
Haemorrhagic events1
  • Cases of pulmonary, gastrointestinal, tumour, urinary tract, and brain haemorrhage, some fatal.
References:Pfizer Laboratories (Pty) Ltd. SUTENT® (sunitinib) 12,5 mg, 25 mg, 50 mg capsules. Final Approved Package Insert - 12 July 2021

Copyright ©2024 Pfizer South Africa All rights reserved.

  • The information contained herein is provided for educational purposes only and is not intended to constitute medical advice or replace discussions with a Healthcare Professional. All decisions regarding patient care must be made with a Healthcare Professional, considering the unique characteristics of the patient.
  • While every effort is made to update the information regularly and to offer the most current, correct and clearly expressed information possible, Pfizer cannot be held responsible for any inaccuracy, errors, omissions or misinterpretations.
  • Pfizer, its officers and/or its employees do not accept or take any responsibility whatsoever for any loss, whether direct, indirect or consequential, which may arise from reliance on information contained on these pages and actions resulting therefrom. Any liability that would or could arise as a result of the contents of these pages is hereby excluded to the fullest extent allowed by law.
  • No warranty is given that any files, downloads or applications available via this web site are free of viruses which have the ability to corrupt your system.
  • Any and all information is subject to change without notice.
  • The information provided in this site is intended only for appropriate Healthcare Professionals residing in South Africa.


PfizerPro AccountPfizerPro Account

To access further materials, resources and receive communication about medicines and vaccines promoted by Pfizer.

Sign inRegisterAccountSign Out

This site is intended only for all Healthcare Professionals residing in South Africa. If you are a member of the public wishing to access information on a specific medicine, please visit


This website is brought to you by Pfizer South Africa 

Pfizer Laboratories (Pty) Ltd. Company Reg. No. 1954/000781/07. Building 2, 1st Floor, Maxwell Office Park, Magwa Crescent, Waterfall City, Midrand, Johannesburg, South Africa. Tel. No: 0860 PFIZER (734937).


Copyright © 2024. Pfizer Laboratories (Pty) Ltd. All rights reserved

For South Africa Healthcare Professionals *

These pages are not intended for patients or for members of the general public. The healthcare professional webpages contain promotional content.

I confirm that I am a healthcare professional residing in South Africa. If you select 'No', you will be redirected to where you will be able to access reference information on Pfizer's prescription medicines.

Yes No
You are now leaving the PfizerPro South Africa website
You are leaving the South Africa HCP Portal website and being directed to a new website

This website is not controlled by South Africa HCP portal or subject to our privacy policy.

Thank you for visiting our site. We hope your visit was informative and enjoyable
You are now leaving PfizerPro You are now leaving PfizerPro and will be directed to our provider to complete your registration. Any personal information that you may find prepopulated from your PfizerPro profile, or you may provide, will be governed by Privacy Policy. Your data will not be used for any other purpose.