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About ZAVICEFTAClinical EfficacySafety and tolerabilityThe ZAVICEFTA patientFull prescribing informationVideo Resources
About ZAVICEFTA
Prescribing information available at the bottom of the page

Broad-spectrum coverage

Mechanism of action

Tab Number 3

ZAVICEFTA® is a broad spectrum cephalosporin active against many Gram-negative and Gram-positive bacterial pathogens in vitro. ZAVICEFTA® inhibits both Ambler class A and class C β-lactamases and some class D enzymes, including ESBLs, KPC and OXA-48 carbapenemases, and AmpC enzymes. 2
FootnoteAvibactam does not inhibit class B enzymes (metallo-β-lactamases) and is not able to inhibit many class D enzymes.

Watch the video below to learn how the combination of ceftazidime and avibactam inhibits a broad range of Gram-negative resistance mechanisms.

PP-ZVA-ZAF-0155


AbbreviationsBL - β-lacatamase; BLI - β-lactamase inhibitor; cIAI - complicated intra-abdominal infection; CRE - carbapenem-resistant Enterobacteriaceae; cUTI - complicated urinary tract infection; ESBL - extended-spectrum β-lacatamase; HABP - hospital-acquired bacterial pneumonia; KPC - Klebsiella pneumoniae carbapenemase; MDR - multidrug-resistant; OXA - oxacillinase; VABP - ventilator-associated bacterial pneumonia.
ReferencesLiscio JLet al. Int J Antimicrob Agents 2015;46:266-71; ZAVICEFTA®South African Approved Professional Information, date of publication: 21 September 2021; Nicolau DPet al. J Antimicrob Chemother 2015;70:2862-9; Stone GG, et al. Antimicrob Agent Chemother 64:e02356-19; Mazuski JEet al. Surg Infect (Marchmnt) 2017;18:1-76; Pogue JMet al. Clin Infect Dis 2019;68:519-24; Zhanel GGet al. Drugs 2013:73:159-77; Lagacé-Wiens P, et al. Core Evid 2014;9:13-25. Bush K,  Int J Antimicrob Agents 2015;46:483-93; Wright Het al. Clin Microbiol Infect 2017;23:704-12; Sader H, et al. Diagn Microbiol Infect Dis 2015;83:389-94; Walkty A,et al. Antimicrob Agents Chemother 2011;55:2992-4; Carmeli Y, et al. Lancet Infect Dis 2016;16:661-73; Torres A,et al. Lancet Infect Dis 2018;18:285-295; Wagenlehner FM,  et al. Clin Infect Dis 2016;63:754-62; Mazuski JE,  et al. Clin Infect Dis 2016;62:1380-9
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*ZAVICEFTA ® South African Approved Professional Information date of publication (21 September 2021). PP-ZVA-ZAF-0029
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