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About ZAVICEFTAClinical EfficacySafety and tolerabilityThe ZAVICEFTA patientFull prescribing informationVideo Resources
Prescribing information available at the bottom of the page

Normal renal function

Renal impairment

Tab Number 3

ZAVICEFTA® has consistent dosing across indications, with no dosage adjustments required in the elderly, patients with mild renal impairment (CrCL 50 - 79 mL/min) or those with hepatic impairment 1

*The dose of ZAVICEFTA® in patients with estimated CrCI ≤50 ml/min should be adjusted according to recommended doses. CrCI estimated using the Cockcroh-Gault formula
† To be used in combination with metronidazole when anaerobic pathogens are known or suspected to be contributing to the infectious process.
‡ To be used in combination with an antibacterial agent active against Gram-positive pathogens when these are known or suspected to be contributing to the infectious process.
§ The total duration shown may include intravenous ZAVICEFTA® followed by appropriate oral therapy. The time to switch from intravenous ZAVICEFTA® to oral treatment with another antibiotic depends on the clinical situation but is normally after about 5 days (the minimum duration of treatment with ZAVICEFTA® in clinical trials was 5 days).

Dosage adjustment is required for patients with renal impairment Recommended dose with renal impairment*
AbbreviationscIAI - complicated intra-abdominal infection; CrCI - creatinine clearance; cUTI - complicated urinary tract infection; HABP - hospital-acquired bacterial pneumonia; VABP - ventilator-associated bacterial pneumonia.
ReferencesZavicefta® South African Approved Professional Information date of publication (21 September 2021)Carmeli Yet al. Lancet Infect Dis 2016;16:661-73;Mazuski JE, et al. Clin Infect Dis 2016;62:1380-9;Wagenlehner FM, et al. Lancet Infect Dis 2016;63:754-62;Torres Aet al. Lancet Infect Dis 2018;18:285-95;Mazuski JEet al. Surg Infect (Marchmnt) 2017;18:1-76;
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*ZAVICEFTA® South African Approved Professional Information date of publication (21 September 2021).PP-ZVA-ZAF-0029
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