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Rheumatoid arthritis (RA) Rheumatoid arthritis (RA) Dosage and Administration Dose Adjustments and Drug Interactions Efficacy Mechanism of Action Prescribing Information Safety Special Populations and Contraindications Special Warnings and Precautions Psoriatic arthritis (PsA) Psoriatic arthritis (PsA) Dosage and Administration Dose Adjustments and Drug Interactions Efficacy Mechanism of Action Prescribing Information Safety Special Populations and Contraindications Special Warnings and Precautions Ulcerative colitis (UC) Ulcerative colitis (UC) Dosage and Administration Dose Adjustments and Drug Interactions Efficacy Mechanism of Action Prescribing Information Safety Special Populations and Contraindications Special Warnings and Precautions
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Abbreviations:PsA: Psoriatic arthritis; RA: Rheumatoid arthritis; UC: Ulcerative colitis; JAK: Janus Kinase; EULAR: European Alliance of Associations for Rheumatology, ACR: American College of Radiology; NPF: National Psoriasis Foundation,
ACG: American College of Gastroenterology
References:Favalli EG, Matucci-Cerinic M, Szekanecz Z. The Giants (biologicals) against the Pigmies (small molecules), pros and cons of two different approaches to the disease modifying treatment in rheumatoid arthritis. Autoimmunity Reviews 2020;19(1):102421.XELJANZ® (tofacitinib citrate) Receives Marketing Authorisation in the European Union for Active Psoriatic Arthritis. [press release] New York, NY: Pfizer Inc.; June 28, 2018. Available at: https://www.pfizer.com/news/press-release/press-release-detail/xeljanz_t.... Accessed March, 2022.Pfizer shares co-primary endpoint results from post-marketing required safety study of Xeljanz® (tofacitinib) in subjects with rheumatoid arthritis (RA). Pfizer. January 2021. Available at https://www.pfizer.com/news/press-release/press-release-detail/pfizer-sh.... Accessed March, 2022.Wollenhaupt J, Lee EB, Curtis JR, et al. Safety and efficacy of tofacitinib for up to 9.5 years in the treatment of rheumatoid arthritis: final results of a global, open-label, long-term extension study. Arthritis Res Ther. 2019;21(1):89.Nash P, Coates LC, Kivitz AJ, et al. Safety and Efficacy of Tofacitinib in Patients with Active Psoriatic Arthritis: Interim Analysis of OPAL Balance, an Open-Label, Long-Term Extension Study. Rheumatol Ther 7, 553–580 (2020). https://doi.org/10.1007/s40744-020-00209-4Sandborn WJ, Panés J, Panaccione R, et al. Tofacitinib for the treatment of ulcerative colitis: Up to 5.4 years of safety data from global clinical trials. Journal of Crohn’s and Colitis 2019;13(S1):S344.Fraenkel L, Bathon JM, England BR, et al. 2021 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis. Arthritis Care Res (Hoboken). Jul 2021;73(7):924-939, doi: 10.1002/acr.24596.Smolen JS, Landewé RB, Bijlsma JW, et. al. EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2019 update. Ann Rheum Dis 2020;79:685–699Singh JA, Guyatt G, Ogdie A, et al. 2018 American College of Rheumatology/National Psoriasis Foundation guideline for the treatment of psoriatic arthritis. Arthritis Rheumatol. 2019;71(1):5-32.Rubin DT, Ananthakrishnan AN, Siegel CA, et al. ACG Clinical Guideline: Ulcerative Colitis in Adults. Am J Gastroenterol 2019;114:384–413.
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